عنوان مقاله [English]
Drug addiction is one of the major concerns of today's society. Drug use causes widespread clinical complications in users. Morphine is a very strong analgesic and narcotic drug that causes biotransformation in the liver, gastrointestinal tract and kidneys and is excreted through the kidneys. This study was performed to evaluate the effect of peritoneal morphine injection in adult male rats in an experimental format based on a completely randomized design with 30 mice in a 28-day breeding period and dividing the mice into control and experimental groups. During the first week of the experiment, all groups used the basal diet to adapt to the conditions of the breeding environment and morphine was then injected daily into the experimental group at a dose (10 mg / kg once daily) for three weeks. At the end of the fourth week, blood samples were taken from the mice after anesthesia, then the mice were killed by amputation of the cervical vertebrae, and after opening the abdominal cavity. The testes and epididymis were removed. Cholesterol, triglyceride, glucose, HDL, LDL, sex hormones (testosterone, FSH, LH) and the number and percentage of sperm survival in the laboratory were determined and the experimental data after normal testing using software SAS was statistically analyzed. The results showed that the effect of peritoneal injection of morphine significantly increased the concentrations of glucose, LDL and testosterone (P <0.05). Also, HDL and triglyceride were not significant on cholesterol concentration but caused a relative increase in cholesterol and a decrease in HDL and triglyceride (P <0.05). It also significantly reduced the number and progress of progress (P <0.05).